“2 random pills” and shoebox pill. Take the shoebox pill, get a shoebox filled with the 2 random pills (since you got one they became “real”). Grab a big handful of pills and swallow.
Others (in case you don’t want to collapse civilization or piss gasoline):
Shoebox + any question = practically unlimited questions. Plus the first one should be something like “how can I achieve maximum happiness (in an easy way where current me would be comfortable with the results)?” and you can ask variations to get a clearer answer since you have practically unlimited ones. Only drawback is if “single-use” really means the duplicates don’t do anything.
Shoebox + groundhog day = probably get to live >10000 years (unless “single-use” prevents that)
Shoebox + pi money = practically unlimited money, no “single use” issue
Shoebox + kill one person = Death Note
Mario’s been watching too much Fox News, they should’ve never brought TVs and cable to Peach’s castle.
I misread the last one as “Drugs as work, happy hours”.