pr0kch0p [she/her]

When you live somewhere the sun is actively trying to kill you 7+ months of the year a tinted windshield does wonders. I have one on my car and I couldn’t tell you the difference between my night vision with the tinted windshield versus untinted. If I can’t see in front of me with time to stop with the light my low beams give, I’m driving too fast.

It does nothing to stop the glare from the massive trucks with the headlights deliberately aligned to shine directly into a passenger car’s cabin. Anyone who drives at night with a tiny that dark is a danger to the public and belongs in the same camp the F350 eyemelter owners end up in for their crimes.

Oh, they’re trying to get rofecoxib back on the market in the US as an orphan drug for hemophilic arthropathy, despite celecoxib already existing and Vioxx having been pulled from the market after Bayer got caught hiding the obscene CV risk profile from the public. Once it’s available for people with joint damage from hemophilia there’s nothing (except a REMS program robust enough to keep it from coming back to market which, lol lmao) to stop it from being prescribed to anyone for anything.

All of the NSAIDs have some combination of GI, CV, and nephrotoxicity risks. Celecoxib is the least worst of them, but it still exists in the shadow of Vioxx. The conventional NSAIDs (except for naproxen and aspirin) are all associated with varying degrees of GI or CV risk and nephrotoxicity. It’s a class effect, some are worse than others, celecoxib and naproxen seem to have the best risk/benefit ratio for people who can take NSAIDs.

The 10% alcohol in this is less concerning than the absolute quantity of acetaminophen in the bottle. Acute co-ingestion of APAP and alcohol isn’t especially dangerous. Alcohol and APAP both deplete liver stores of glutathione, which one’s body uses to neutralize toxic metabolites of both substances as you mentioned. Chronic co-ingestion can cause fulminant liver failure pretty suddenly, as can acute co-ingestion of both substances in large enough quantities.

Some people are able to take what should be lethal doses of acetaminophen for prolonged periods of time with no issues, other people are uniquely susceptible to the toxic effects. The only way to find out which camp you’re in is if you end up with liver damage!

Ibuprofen has its own risks and is not nearly as benign as it’s made out to be. It won’t cause acute liver failure but taken at usual doses for long enough will give you an ulcer and utterly shred your kidneys. People who are hypocoagulable (on blood thinners/various psych meds or have an inborn or acquired bleeding disorder) shouldn’t or can’t take NSAIDs. They’re contraindicated in kidney failure, too.

All that to say the ease with which one can acquire lethal amounts of OTC painkillers in North America is a problem! If this were a saner country this wouldn’t be on the market, APAP wouldn’t be available in any combination products, and there would be quantity limits on how much you could buy at a time.

I’ve had the displeasure of almost needing a liver transplant from acetaminophen poisoning. Two weeks in the ICU in indescribable pain, then my liver decided it was fine, actually. I recovered with my factory liver intact and no sequelae but it’s not worth risking, ever.

Opana was everywhere for a few years before it got reformulated shortly after OCs. Generic oxymorphone tabs still exist but good luck finding them. Too good for this world.

Leuchtturm 1917 and Rhodia both make great notebooks. Depending on where you go the price point is similar but they’re a joy to write in, the paper is way better quality than Moleskine.