A new discovery reveals that astrocytes, star-shaped cells in the brain, play a key role in regulating fat metabolism and obesity. These cells act on a cluster of neurons, known as the GABRA5 cluster, effectively acting as a “switch” for weight regulation.
The MAO-B enzyme in these astrocytes was identified as a target for obesity treatment, influencing GABA secretion and thus weight regulation.
KDS2010, a selective and reversible MAO-B inhibitor, successfully led to weight loss in obese mice without impacting their food intake, even while consuming a high-fat diet, and is now in Phase 1 clinical trials.
Since nobody else who answered you read the article:
Heat. They discovered a way to trigger the part of the brain that regulates heat production by brown fat tissue.
Nothing that could go wrong with raising body temp permanently…
Just in! Man takes too many weightloss pills, ends up inadvertently cooking his testes! Read all about it in Blabbity Fair!
And in a world that is getting hotter and hotter, nothing is more appealing than carrying your own furnace with you, wherever you go.
That’s kind of what DNP does. Side effects include death
That’s the bit they mentioned, anyway. It sounds like in this scenario they tried two different diets, and the higher-calorie one produced more body heating. I imagine appetite regulation would also play a part “in the wild”.